Selenium-binding protein 1 (SBP-1) is a 56 kD cytosolic protein bound to selenium by selenosulfide covalent bond. It enhances the production of reactive oxygen species and aggravates the oxidative stress. Significant high urinary levels observed in acute kidney injury. This cross-sectional observational study aimed to assess the clinical significant of determining the serum level of SBP-1 in patients with chronic kidney disease (CKD). A total number of 125 patients with established CKD, and 30 healthy subjects were recruited from Rizgary Teaching Hospital in Erbil-Iraq from January to August 2018. Anthropometric, blood pressure, and estimated glomerular filtration rate (eGFR) were determined. Serum SBP-1 was determined by using enzyme linked immunoassay technique. The mean ± SD of serum SBP-1 level was significantly (p<0.001) higher in CKD than the corresponding level of healthy subjects (2009 ± 857.4 vs. 920.6 ± 288.3 pg/ml), respectively. Significant positive correlation between eGFR with serum level of SBP-1 (r=0.188, p=0.036) was observed. Receiving operating characteristics test shows that the area under the curve of the waist to height ratio was significantly high at a cut-off value of SBP-1 is 1500 pg/ml. The sensitivity, the specificity, and the positive predictive value of this discriminator were 61.6%, 100%, and 77%, respectively. We conclude that serum SBP-1 significantly correlates with eGFR, and it is a useful discriminator of cardiovascular events that represented by a significant the area under the curve of waist to height ratio.