Follistatin (FST) is glycoprotein, otherwise called activin restricting protein, is an endogenously created protein that ties activin A with high fondness and restrains its bioactivity. The essential capacity of FST is the authoritative and bioneutralization of individuals from the TGF-β superfamily and activin A specifically. FST advances adipogenic separation of begetter cells. FST has been embroiled in aggravation and renovating, any adjustment in the level of FST, which might be a determinant of the seriousness of irritation, or tissue phenotypic change. Atherosclerosis is a dynamical procedure that rises up out of the interchange between lipid digestion, irritation and inborn insusceptibility. The blood vessel area of atherosclerosis makes it strategically and morally hard to think about in vivo. To enhance our comprehension of the infection, we should discover elective approaches to research its movement. The points of this investigation; we need to know the connection between the serum FST level with atherosclerosis malady and its relationship with some deliberate rule, for example, sex, age, BMI, waist circumference and smoking.