Streptococcus pneumoniae is an important pathogen, which is mainly the causative agent of pneumonia. The limited treatment and control options mean refers an urgent need for novel effective therapies to treat infected patients. The study has described one approach of controlling and treating this pathogen using Salvadora persica. An extract from different parts of this plant has been used including twigs, fruit, and root. All extracts were shown to clear pneumococci lawns on solid media. However, fruit extract showed a considered reduction in pneumococcal colony forming unit (CFU) in liquid culture. This represents a promising therapeutic strategy against pneumococcal infection in particular by highly invasive strains that have evaded vaccination, or are resistant to existing antibiotics.