ISSN: 0970-938X (Print) | 0976-1683 (Electronic)

Biomedical Research

An International Journal of Medical Sciences

All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission System of respective journal.

Abstract

Antimicrobial activities of some synthesized macrocyclic pentaazapyridine and dipeptide pyridine derivatives

A series of tetracarboxamide Schiff base and macrocyclic pentaazapyridines has been prepared from 3,5-bis(N-(1-hydrazinyl-1-oxo-3-phenylpropan-2-yl))pyridine carboxamide 4 as starting material, which was synthesized from 3,5-dinicotinic acid 1. Treatment of 4 with 1,4-diaminobutane, 1,6-diaminohexane or cycloalkanone derivatives gave the corresponding macrocyclic tetracarboxamides 5a and 5b, and cycloalkyl Schiff bases 6a-6c, respectively. Treatment of 4 with acetophenone or acetylpyridine derivatives gave the corresponding Schiff bases 7a-7e and 8a-8c, respectively. Carboxylic acid hydrazide 4 was treated with acid anhydrides in glacial acetic acid to afford the corresponding diimide tetracarboxamides 9-11, respectively. The structures of newly synthesized compounds are established by physical and spectral data evidences. Some of the synthesized compounds were screened as antimicrobial agents.


Author(s): Eman M. Flefel, Mona A. Alsafi, Sana M. Alahmadi, Abd El-Galil E. Amr

Abstract | Full-Text | PDF

Share this  Facebook  Twitter  LinkedIn  Google+