Coronary artery disease is the single most important disease entity in terms of both mortal-ity and morbidity in the entire world population. Both men and women between the age group 40 to 60 years are susceptible to it. Prevention of coronary artery disease can be ap-proached in many ways including healthy promotion campaign, specific protection strate-gies, life style modification programs, early detection and control of risk factors and con-stant vigilance of emerging risk factors. Novel factor like plasma homocysteine has been re-cently recognized as independent risk factor for coronary artery disease. So, an attempt has been made to evaluate the risk factor for coronary artery disease in diabetics. In the present study, 50 diabetic patients with raised glycosylated haemoglobin in the age range of 30-60 years and equal number of age and sex matched normal healthy subjects (control) were re-cruited. The levels of plasma homocysteine in diabetic patients was found to be significantly increased (p<0.001) with respect to control group. The study therefore suggests the impor-tance of assessing plasma homocysteine (primarily atherogenic marker) along with other routine investigations in diabetic patients in addition to primary and secondary preventives measures to migrate the devastating consequences of diabetes leading to coronary artery disease.