Biomedical Research

Objective: To study the protecting effect of combining probiotics with Glutamine (Gln) in intestinal barrier function of severe surgical patients.

Methods: A total of 36 surgical patients with severe gastrointestinal diseases were randomly divided into routine Parenteral Nutrition (PN) group, probiotics group, and combination group, which received conventional PN, PN+probiotics and PN+probiotics+GLn respectively. Then all groups were measured the ratio of lactulose and Mannitol (L/M), the concentration of serum endotoxin, the level of intestinal Lactobacillus, and the number of gram-negative bacterium before operation and at the 3^rd, 8^th day after operation.

Results: At 8^th day, the ratio of lactulose and mannitol levels as well as the concentration of serum endotoxin in the probiotics group were much lower than those in the PN group (P<0.05), but much higher than the combination group (P<0.05)The level of intestinal Lactobacillus in the probiotics group was much higher than that in the PN group (P<0.05), but lower than the combination group (P<0.05). There was no significant difference in the number of gram-negative bacterium among the three groups (P>0.05).

Conclusions: Addition of probiotics to Gln therapy has better protecting effect in intestinal barrier function.

Author(s): Baohua Wang, Yinhua Wang, Yingang Zhang, Haixia Chai, Xingwei Xuan
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